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KMID : 1134820200490111202
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Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 11 p.1202 ~ p.1211
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Anti-Inflammatory Effects of BENDU381 in Lipopolysaccharide-Stimulated RAW264.7 Cells
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Shin Jin-A
Jeong Jong-Moon
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Abstract
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BENDU381, a nutraceutical composed of extracts from green tea (Camellia sinensis), guajava leaves (Psidium guajava) and rose petals (Rosa hybrida), has been previously shown to improve allergic inflammation and has also been evaluated for its therapeutic effect on allergic rhinitis. In this study, we examined the anti-inflammatory effect of BENDU381 on lipopolysaccharide (LPS)-stimulated mouse macrophage, RAW264.7 cells, and the molecular mechanisms responsible for its anti-inflammatory activity. BENDU381 significantly suppressed the expression of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, as well as cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) I the LPS-stimulated RAW264.7 cells. Also, BENDU381 inhibited LPS-induced activation of nuclear factor (NF)-κB by dampening the activation of the mitogen-activated protein kinases (MAPKs) pathway including c-Jun N-terminal kinase (JNK) and extracellular-signal-regulated kinase (ERK) which are responsible for the expression of pro-inflammatory mediators. These results suggest that BENDU381 has strong anti-inflammatory activities and its effect in the mouse macrophages is mediated by the blockage of NF-κB-JNK/ERK MAPKs signaling pathway.
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KEYWORD
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BENDU381, anti-inflammatory, macrophage, cytokines, MAPKs
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